Phosphaplatins, next generation platinum antitumor agents: A paradigm shift in designing and defining molecular targets

► Phosphaplatins exhibit less toxicity compared to cis- and carbo-platin. ► Phosphaplatins exhibit excellent in vivo efficacy in human ovarian cancers. ► Phosphaplatins are effective against sensitive and resistant human cancer cells. ► Phosphaplatins showed reduce protein binding compared to cis- and carbo-platin. ► Phosphaplatins are promising antitumor agents to treat resistant cancers.