Gradient coatings of strontium hydroxyapatite/zinc β-tricalcium phosphate as a tool to modulate osteoblast/osteoclast response

Combinatorial Matrix-Assisted Pulsed Laser Evaporation technique allows to deposit thin films with tailored compositions of Sr-substituted hydroxyapatite (SrHA) and Zn-substituted β-tricalcium phosphate (ZnTCP), which modulate promotion of osteoblast viability and activity, as well as inhibition of osteoclastogenesis and osteoclast differentiation.134