Anticancer Ru(η6-p-cymene) complexes of 2-pyridinecarbothioamides: A structure-activity relationship study

This paper aimed to develop structure-activity relationships for pyridine-2-carbothiamide-based organometallics that are orally active anticancer agents. The lipophilic nature of the ligands correlated well with the cytotoxicity of the complexes prepared.138