Increasing DNA reactivity and in vitro antitumor activity of trans diiodido Pt(II) complexes with UVA light

Trans diiodido platinum(II) complexes bearing the same as well as different aliphatic amines (mixed-amines) are examined in detail: cytotoxicity and interactions with some important biological models. Interestingly, UV irradiation of these compounds results in an increase in reactivity towards DNA in such model systems. Additionally, the cytotoxicity is noticeably increased by UV-light over short treatment times.146