Progressive inflammatory pathology in the retina of aluminum-fed 5xFAD transgenic mice

The 5xFAD transgenic Alzheimer's disease (AD) mouse-model exhibits progressive amyloidogenesis; aluminum-fed 5xFAD mice display accelerated amyloid deposition. 5xFAD animals also display up-regulation of the inflammatory-biomarkers COX-2 and CRP; for the first time we demonstrate the propagation of AD-type change into the retina; this may have relevance for 'pathological spreading' mechanisms.