New bioactive 2,6-diacetylpyridine bis(p-chlorophenylthiosemicarbazone) ligand and its Pd(II) and Pt(II) complexes: Synthesis, characterization, cytotoxic activity and DNA binding ability

2,6-diacetylpyridine bis(4N-p-chlorophenylthiosemicarbazone) ligand, H2L, and its [PdL] and [PtL] complexes have been synthesized and characterized. The cytotoxicity data suggest that H2L and [PtL] compounds may be endowed with important antitumor properties. The interaction of H2L with calf thymus DNA was also investigated and its binding constant (Kb) determined.55