Silver(I)/6-hydroxyiminolumazine compounds differently modify renin-angiotensin system-regulating aminopeptidases A and N in human neuroblastoma and glioma cells

The in vitro analysis of both antiproliferative efficacy and effects on RAS-regulating APA and APN activities of new disilver-6-hydroxyiminolumazine complexes on the human neuroblastoma and glioma cell lines NB69 and U373-MG allows us to propose them as compounds with specific antitumor activity against brain tumor cells, mainly glioma.273