Re(I) tricarbonyl complex of 1,10-phenanthroline-5,6-dione: DNA binding, cytotoxicity, anti-inflammatory and anti-coagulant effects towards platelet activating factor

The affinity and mode of complex fac-[Re(CO)3(phendione)Cl] and its constituents [Re(CO)5Cl] and phendione binding to DNA, as well as their ability to cleave single-strand DNA were determined by physico-chemical techniques, whereas biological activities were derived from the cytotoxicity, platelet aggregation and enzyme inhibition assays.