Biological evaluation of bismuth non-steroidal anti-inflammatory drugs (BiNSAIDs): Stability, toxicity and uptake in HCT-8 colon cancer cells

In light of recent studies that link COX-2 up-regulation to colorectal cancer, research is being performed to explore the potential of metal NSAIDs as anti-cancer agents with enhanced gastroprotective properties. The stability, toxicity and cellular uptake of BiNSAIDs towards HCT-8 human ileocecal colon cancer cells are presented.