Cadmium coordination to the zinc binding domains of the non-classical zinc finger protein Tristetraprolin affects RNA binding selectivity

► Cd(II) coordination to the non-classical zinc finger protein Tristetraprolin (TTP-2D). ► Cd(II)-TTP-2D binds AU-rich RNA molecules. ► Cd(II)-TTP-2D binds AU-rich RNA molecules with greater selectivity than native Zn(II)-TTP-2D.