Caffeine derived platinum(II) N-heterocyclic carbene complexes with multiple anti-cancer activities

The caffeine derived organometallic platinum(II) complex [PtII(2,2′:6′,2″-terpyridine) (1,3,7,9-tetramethylxanthine-8-ylidene)](PF6)2 (1) displayed dual cytotoxic and anti-angiogenic anti-cancer activities, and induced neural differentiation-like morphological changes in breast adenocarcinoma (MCF-7) cells.178