کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7764828 | 1500237 | 2015 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Potential anticancer activity of benzimidazole-based mono/dinuclear Zn(II) complexes towards human carcinoma cells
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Potential anticancer activity of benzimidazole-based mono/dinuclear Zn(II) complexes towards human carcinoma cells Potential anticancer activity of benzimidazole-based mono/dinuclear Zn(II) complexes towards human carcinoma cells](/preview/png/7764828.png)
چکیده انگلیسی
To investigate the biological activities of Zn(II) complexes, two mono/dinuclear Zn(II) complexes, Zn2(p-2-bmb)2 (NO3)2 (1) and Zn(p-2-bmp)2Cl2 (2), were constructed from V-shape flexible benzimidazole-based ligands. Compared with complex 2, in cytotoxicity research, 1 showed higher cytotoxic properties in vitro against SHSY5Y cells. The interaction of complex 1 with calf thymus DNA is not the classical intercalation binding. Flow cytometry analyses demonstrated that complex 1 arrested the cells in the G0/G1 phase with a dose-dependent manner. In addition, the morphological changes and membrane permeability changes also provide evidence that 1 could induce apoptosis.144
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polyhedron - Volume 102, 14 December 2015, Pages 163-172
Journal: Polyhedron - Volume 102, 14 December 2015, Pages 163-172
نویسندگان
Jin'an Zhao, Yan Guo, Jiyong Hu, Huaibin Yu, Shuangcheng Zhi, Junshuai Zhang,