The synthesis and biological evaluation of alkyl and benzyl naphthyridinium analogs of eupolauridine as potential antimicrobial and cytotoxic agents

A series of alkyl and benzyl naphthyridinium analogs of the natural product eupolauridine were prepared and evaluated for their antifungal, antibacterial and antimalarial activities. Several compounds showed antifungal, antibacterial and antimalarial activity to varying degrees. Some of them were cytotoxic to human cancer cell lines.