کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7781437 | 1500560 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Rhizopus nigricans polysaccharide activated macrophages and suppressed tumor growth in CT26 tumor-bearing mice
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کلمات کلیدی
NF-κB5-FUHPSEC-MALLSPMBRhizopus nigricansMAPKs - MAPK هاAntitumor - ضد تومورnuclear factor-κB - فاکتور هسته ای κB5-fluorouracil - فلوروراسیل-۵، فلوئورواوراسیلMacrophage - ماکروفاژ Nitric oxide - نیتریک اکسیدpolymyxin B - پلی مکسین BPolysaccharides - پلیساکاریدهاmitogen-activated protein kinases - کیناز پروتئین فعال Mitogen
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this study, a homogeneous polysaccharide (RPS-1) was extracted from liquid-cultured mycelia of Rhizopus nigricans. The weight-average molecular weight of RPS-1 was 1.617â¯Ãâ¯107 g/mol and structural characterization indicated that RPS-1 was a non-starch glucan which consisted of a backbone structure of (1â4)-linked α-d-glucopyranosyl residues substituted at the O-6 position with α-d-glucopyranosyl branches. RPS-1 stimulated the production of nitric oxide and tumor necrosis factor-α by triggering phosphorylation of mitogen-activated protein kinases and nuclear translocation of nuclear factor kappa B p65 in RAW 264.7 macrophage cells. Moreover, intragastric administration of RPS-1 improved the immune function of CT26 tumor-bearing mice and significantly inhibited the growth of transplanted tumor. In combination with 5-FU, RPS-1 enhanced antitumor activity of 5-FU and alleviated its toxicity on immune system. These findings suggested that RPS-1 has the potential for the development of functional foods and dietary supplements.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 198, 15 October 2018, Pages 302-312
Journal: Carbohydrate Polymers - Volume 198, 15 October 2018, Pages 302-312
نویسندگان
Zhihong Wei, Guochuang Chen, Pengying Zhang, Lei Zhu, Linan Zhang, Kaoshan Chen,