کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7782598 | 1500566 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Physical and chemical properties, percutaneous absorption-promoting effects of exopolysaccharide produced by Bacillus atrophaeus WYZ strain
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Physical and chemical properties, percutaneous absorption-promoting effects of exopolysaccharide produced by Bacillus atrophaeus WYZ strain Physical and chemical properties, percutaneous absorption-promoting effects of exopolysaccharide produced by Bacillus atrophaeus WYZ strain](/preview/png/7782598.png)
چکیده انگلیسی
A high yield of exopolysaccharides bacteria isolated from mangrove system was identified as Bacillus atrophaeus by 16S rDNA and named as WYZ strain. An exopolysaccharide (BPS) was obtained from this strain after purification with a yield of about 0.58â¯g/L. Then some physical and chemical properties of BPS, such as weight average molecular weight (Mw), monosaccharide composition, intrinsic viscosity and water retention capacity were studied. The microstructure (SEM) showed that BPS was porous wound three-dimensional spider web structure. Using BPS as transdermal absorption enhancer, and lidocaine as a test drug, in vitro and local anesthesia in live animals experiments were conducted to explore that the BPS promote lidocaine transdermal absorption and mechanism. In conclusion, the BPS had good water retention capacity and transdermal absorption promoting effect, all of these indicated that BPS has great potential in the field of biomaterials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 192, 15 July 2018, Pages 52-60
Journal: Carbohydrate Polymers - Volume 192, 15 July 2018, Pages 52-60
نویسندگان
Wenjing Zhu, Yuzhen Wang, Fang Yan, Ruiteng Song, Zhijian Li, Yiqing Li, Bo Song,