کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7783974 1500574 2018 35 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thermo-sensitive injectable glycol chitosan-based hydrogel for treatment of degenerative disc disease
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Thermo-sensitive injectable glycol chitosan-based hydrogel for treatment of degenerative disc disease
چکیده انگلیسی
The use of injectable hydrogel formulations have been suggested as a promising strategy for the treatment of degenerative disc disease to both restore the biomechanical function and reduce low back pain. In this work, a new thermo-sensitive injectable hydrogels with tunable thermo-sensitivity and enhanced stability were developed with N-hexanoylation of glycol chitosan (GC) for treatment of degenerative disc disease, and their physico-chemical and biological properties were evaluated. The sol-gel transition temperature of the hydrogels was controlled in a range of 23-56 °С, depending on the degree of hexanoylation and the polymer concentration. In vitro and in vivo tests showed no cytotoxicity and no adverse effects in a rat model. The hydrogel filling of the defective IVD site in an ex vivo porcine model maintained its stability for longer than 28 days. These results suggest that the hydrogel can be used as an alternative material for treatment of disc herniation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 184, 15 March 2018, Pages 342-353
نویسندگان
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