کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7783986 | 1500574 | 2018 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Photopolymerized maleilated chitosan/thiol-terminated poly (vinyl alcohol) hydrogels as potential tissue engineering scaffolds
ترجمه فارسی عنوان
هیدروژل پلی (وینیل الکل) هیدروژل پلی اورتان / پلی اورتان / پلی اورتان / پلی اورتان /
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کلمات کلیدی
هیدروژل، کیتوزان، پلی وینیل الکل)، عکسبرداری، داربست مهندسی بافت،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Photocrosslinkable hydrogels composed of natural materials exhibit great application potential in tissue engineering scaffolds. However, weak formation and poor mechanical property can usually be a limitation. Herein, the photo-clickable thiol-ene hydrogels based chitosan were synthesized using photopolymerization of maleic chitosan (MCS) and thiol-terminated poly (vinyl alcohol) (TPVA) in the presence of a biocompatible photoinitiator. Rheological property and absorbing behavior of the MCS/TPVA hydrogels could be tailored by varying the amount of TPVA in the feed. There was strong intermolecular hydrogen bonding between the molecules of MCS and TPVA. Notably, the MCS/TPVA hydrogel (MT-3) exhibited rapid gelation behavior (<120â¯s), improved stiff (G'â¯=â¯â¼5500â¯Pa) and compressive strength (0.285â¯Â±â¯0.014â¯MPa), which were important for hydrogel scaffolds, especially for injectable hydrogel scaffolds. Photocrosslinked MCS/TPVA hydrogels was cytocompatible and could promote the L929 cells attachment and proliferation, showing their potential as tissue engineering scaffolds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 184, 15 March 2018, Pages 383-389
Journal: Carbohydrate Polymers - Volume 184, 15 March 2018, Pages 383-389
نویسندگان
Yingshan Zhou, Shuyan Zhao, Can Zhang, Kaili Liang, Jun Li, Hongjun Yang, Shaojin Gu, Zikui Bai, Dezhan Ye, Weilin Xu,