کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7784744 | 1500577 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fabrication of photo-crosslinkable glycol chitosan hydrogel as a tissue adhesive
ترجمه فارسی عنوان
تولید هیدروژل کیتوزان گلیکول براق عکس به عنوان یک چسب بافت
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کلمات کلیدی
گلیکول کیتوزان، هیدروژل، پیوند فتوشیمیایی، هموستاز، چسب بافت ضد باکتری،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
In this work, an in situ gelling system composed of glycol chitosan (GC) was fabricated and evaluated regarding its tissue-adhesive, anti-bacterial and hemostatic properties. GC conjugated with 3-(4-hydroxyphenyl) propionic acid gelled immediately after illumination with blue light in the presence of ruthenium complex. The phenolic GC hydrogel was investigated regarding its mechanical property, hydration, degradation rate, cytotoxicity, tissue adhesiveness, and hemostatic ability. The hydrogel was shown to glue two pieces of tissues tightly in an egg-membrane model. The antibiotic-incorporated hydrogel killed bacteria effectively. When the hydrogel was applied to a wound in a mouse liver model, bleeding was reduced quickly and greatly. All the promising results show that the photo-chemically crosslinkable GC hydrogel could be used as a tissue adhesive, controlled drug release, and a hemostat.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 181, 1 February 2018, Pages 668-674
Journal: Carbohydrate Polymers - Volume 181, 1 February 2018, Pages 668-674
نویسندگان
Min Lu, Yi Liu, Yung-Chi Huang, Chun-Jen Huang, Wei-Bor Tsai,