کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7785129 | 1500605 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Optimization of hyaluronan-based eye drop formulations
ترجمه فارسی عنوان
بهینه سازی فرمولاسیون قطره چشم مبتنی بر هیالورونان
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کلمات کلیدی
هیالورونان، قطره چشم، ویسکوزیته، مخاطی مضر، سلول های اپیتلیال قرنل،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Hyaluronan (HA) is frequently incorporated in eye drops to extend the pre-corneal residence time, due to its viscosifying and mucoadhesive properties. Hydrodynamic and rheological evaluations of commercial products are first accomplished revealing molecular weights varying from about 360 to about 1200Â kDa and viscosity values in the range 3.7-24.2Â mPa s. The latter suggest that most products could be optimized towards resistance to drainage from the ocular surface. Then, a study aiming to maximize the viscosity and mucoadhesiveness of HA-based preparations is performed. The effect of polymer chain length and concentration is investigated. For the whole range of molecular weights encountered in commercial products, the concentration maximizing performance is identified. Such concentration varies from 0.3 (wt%) for a 1100Â kDa HA up to 1.0 (wt%) for a 250Â kDa HA, which is 3-fold higher than the highest concentration on the market. The viscosity and mucoadhesion profiles of optimized formulations are superior than commercial products, especially under conditions simulating in vivo blinking. Thus longer retention on the corneal epithelium can be predicted. An enhanced capacity to protect corneal porcine epithelial cells from dehydration is also demonstrated in vitro. Overall, the results predict formulations with improved efficacy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 153, 20 November 2016, Pages 275-283
Journal: Carbohydrate Polymers - Volume 153, 20 November 2016, Pages 275-283
نویسندگان
Rosanna Salzillo, Chiara Schiraldi, Luisana Corsuto, Antonella D'Agostino, Rosanna Filosa, Mario De Rosa, Annalisa La Gatta,