کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7786432 | 1500622 | 2016 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dual pH and temperature responsive hydrogels based on β-cyclodextrin derivatives for atorvastatin delivery
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Dual pH and temperature responsive hydrogels based on β-cyclodextrin derivatives for atorvastatin delivery Dual pH and temperature responsive hydrogels based on β-cyclodextrin derivatives for atorvastatin delivery](/preview/png/7786432.png)
چکیده انگلیسی
2-Methylacrylic acid modified β-cyclodextrin was copolymerized with 2-methylacrylic acid and N,Nâ²-methylene diacrylamide to fabricate dual pH and temperature responsive hydrogels for the controlled release of atorvastatin. The swelling behaviors, pH and temperature responsive atorvastatin release profiles of the hydrogels were investigated. The results indicated that the hydrogel prepared in DMSO exhibited the best swelling rate, which was 51 for 10 min and 252 for 16 h when immersed in medium of buffer solution with pH = 8.06. The media with low (pH â¤Â 3.84) and high (pH â¥Â 10.34) pH values would reduce the swelling rate of hydrogels. The swelling of the hydrogel was increased with increasing temperature from 30 °C to 45 °C. Atorvastatin was loaded in the hydrogel for drug release investigation. The cumulative release rate of atorvastatin was as high as 90.5% in pH = 8.06 buffer solution. The solubility of atorvastatin was improved from 0.13 to 1.2 mg/mL in the hydrogel.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 136, 20 January 2016, Pages 300-306
Journal: Carbohydrate Polymers - Volume 136, 20 January 2016, Pages 300-306
نویسندگان
Kaiwen Yang, Sicheng Wan, Binbin Chen, Wenxia Gao, Jiuxi Chen, Miaochang Liu, Bin He, Huayue Wu,