کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7787178 1500624 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of tiopronin, captopril and levamisole therapeutics on the oxidative degradation of hyaluronan
ترجمه فارسی عنوان
تأثیر داروهای تیوپرینین، کپتوپریل و لوامیزول بر تخریب اکسیداتیو هیالورونان
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
The ability to protect hyaluronic acid (HA) from oxidative degradation by cupric ions and ascorbate (production of OH and peroxy-type radicals) during acute phase joint inflammation has been investigated using the following drugs: tiopronin, captopril, and levamisole. Radical scavenging activity, i.e. the propensity for donation of electrons was assessed for the drugs by ABTS and DPPH assays. The kinetics of HA degradation have been measured in the presence of each drug using rotational viscometry. The results of ABTS and DPPH assays show the highest radical scavenging activity for captopril, followed by tiopronin. For levamisole, no effect was observed. Captopril and tiopronin prevented HA degradation induced by OH radicals in a similar manner, while tiopronin was more effective in scavenging peroxy-type radicals. On the other hand, levamisole was shown to be a pro-oxidant. Recovered HA fragments were characterized using FT-IR analysis, the incorporation of a sulphur atom from captopril and tiopronin but not from levamisole into the HA molecule was demonstrated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 134, 10 December 2015, Pages 516-523
نویسندگان
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