کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7787438 | 1500626 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Purification, structural characterization and anticancer activity of the novel polysaccharides from Rhynchosia minima root
ترجمه فارسی عنوان
خالص سازی، ویژگی های ساختاری و فعالیت ضد سرطان پلی ساکارید های جدید از ریشه های راینچوسیا ریشه
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
رینچوسیا حداقل، پلی ساکارید، پاکسازی، ضد سرطان،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Three novel acidic polysaccharides termed PRM1, PRM3 and PRM5 were purified from Rhynchosia minima root using DEAE-52 cellulose and sephadex G-150 column chromatography. Their structures were characterized by ultraviolet (UV) and Fourier transform infrared (FTIR) spectrometry, gel permeation chromatography (GPC), gas chromatography-mass spectrometry (GC-MS), and differential scanning colorimeter (DSC) analysis. The uronic acid contents of PRM1, PRM3 and PRM5 were 30.7%, 12.7% and 47.7%, respectively. PRM1 (143.2Â kDa), PRM3 (105.3Â kDa) and PRM5 (162.1Â kDa) were heteropolysaccharides because they were composed of arabinose, mannose, glucose and galactose. Their enthalpy values were 201.0, 111.0 and 206.8Â J/g, respectively. PRM3 and PRM1 exhibited strong in vitro anticancer activity against lung cancer A549 and liver cancer HepG2 cells in a dose-dependent manner. These findings suggested that PRM1 and PRM3 could be potentially developed as natural anticancer agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 132, 5 November 2015, Pages 67-71
Journal: Carbohydrate Polymers - Volume 132, 5 November 2015, Pages 67-71
نویسندگان
Xuejing Jia, Chao Zhang, Jianfeng Qiu, Lili Wang, Jiaolin Bao, Kai Wang, Yulin Zhang, Meiwan Chen, Jianbo Wan, Huanxing Su, Jianping Han, Chengwei He,