کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7787654 | 1500625 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chondroitin sulfate-based nanocarriers for drug/gene delivery
ترجمه فارسی عنوان
نانوذرات مبتنی بر سولفات کندرویتین برای تحویل دارو / ژن
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کلمات کلیدی
کندرویتین سولفات، پلی ساکارید، نانوکاریس، سیستم تحویل دارو / ژن
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
In recent years, the naturally occurring polysaccharides captured an increasing amount of attention in the field of drug/gene delivery systems owing to their outstanding propensities, including biocompatibility, biodegradability, non-immunogenicity, extremely low toxicity, and so on. Chondroitin sulfate (ChS), a member of glycosaminoglycan family, consists of repeating disaccharide units of b-1,3-linked N-acetyl galactosamine (GalNAc) and b-1,4-linked d-glucuronic acid (GlcA) with certain position(s) sulfated, which has been widely applied in nano-sized carriers. This review will focus on shared and unique properties of ChS and its latest development in drug/gene delivery systems. In detail, the application of ChS as nanocarriers will be discussed in three dimensions: self-assembly of hydrophobically modified ChS, ChS decorated nanocarriers, and some other nanocarriers based on ChS. A discussion relating to the future perspectives of ChS-based nanocarriers for drug/gene delivery is also included.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 133, 20 November 2015, Pages 391-399
Journal: Carbohydrate Polymers - Volume 133, 20 November 2015, Pages 391-399
نویسندگان
Lili Zhao, Mengrui Liu, Juan Wang, Guangxi Zhai,