کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7788522 | 1500631 | 2015 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Formulation and process optimization of naproxen nanosuspensions stabilized by hydroxy propyl methyl cellulose
ترجمه فارسی عنوان
فرمولاسیون و بهینه سازی فرآیند نانوذرات ناپروکسن که توسط هیدروکسی پروپیل متیل سلولز تثبیت شده است
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
In present study precipitation-ultrasonication was used to obtain nanosuspensions of poorly water-soluble drug, naproxen (NPX). We investigated the effects of HPMC concentration (X1) and time of ultrasonication (X2) on imperative attributes like mean particle size (Y1), % drug content (Y2), and time required to 90% drug release (Y3) via 32 factorial design. The morphology of nanosuspensions was found almost spherical by SEM observation. DSC and XRD studies suggested slight crystalline change in drug. FT-IR revealed lack of significant interactions between NPX and HPMC. Nanosuspensions of mean particle size 530.55Â nm was achieved. Dissolution rate obtained from all nanosuspensions were markedly higher than pure NPX. Response surface methodology and optimized polynomial equations were used to select optimal formulation i.e. 1.36%W/V of X1 and 13.9Â min of X2 to get desired response Y1; 727.97Â nm, Y2; 95.59% and Y3; 8.67Â min that were in reasonable agreement with observed value.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 127, 20 August 2015, Pages 300-308
Journal: Carbohydrate Polymers - Volume 127, 20 August 2015, Pages 300-308
نویسندگان
Bibaswan Mishra, Jagannath Sahoo, Prasanna Kumar Dixit,