کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7788643 1500633 2015 28 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel zinc alginate hydrogels prepared by internal setting method with intrinsic antibacterial activity
ترجمه فارسی عنوان
هیدروژل آلژینات روی رول با روش تنظیم داخلی با فعالیت ضد میکروبی داخلی آماده شده است
کلمات کلیدی
آلژینات روی، ژلینگ داخلی، فعالیت ضد باکتری، پانسمان زخم،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
In this paper, a controlled gelation of alginate was performed for the first time using ZnCO3 and GDL. Uniform and transparent gels were obtained and investigated as potential wound dressings. Homogeneity, water content, swelling capability, water evaporation rate, stability in normal saline solution, mechanical properties and antibacterial activity were assessed as a function of zinc concentration. Gelation rate increased at increasing zinc content, while a decrease in water uptake and an improvement of stability were found. Release of zinc in physiological environments showed that concentration of zinc released in solution lies below the cytotoxicity level. Hydrogels showed antimicrobial activity against Escherichia coli. The hydrogel with highest zinc content was stabilized with calcium by immersion in a calcium chloride solution. The resulting hydrogel preserved homogeneity and antibacterial activity. Furthermore, it showed even an improvement of stability and mechanical properties, which makes it suitable as long-lasting wound dressing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 125, 10 July 2015, Pages 103-112
نویسندگان
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