کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7788746 1500633 2015 31 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Surface characterization and drug release from porous microparticles based on methacrylic monomers and xanthan
ترجمه فارسی عنوان
خصوصیات سطح و انتشار مواد مخدر از میکروپارس های متخلخل بر اساس مونومرهای متاکریل و زانتان
کلمات کلیدی
میکروارگانیسم های متخلخل، مونومرهای متاکریل، کسانتان، مورفولوژی سطح، تئوفیلین،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
Porous crosslinked microparticles based on glycidyl methacrylate and xanthan were prepared by suspension polymerization and used for loading theophylline, a bronhodilatator drug, in order to obtain new drug delivery systems. The surface morphologies observed by means of SEM and AFM analysis demonstrated that microparticles show a spherical shape and are characterized by a porous structure. The presence of xanthan in the structure of microparticles leads to a decrease of surface roughness and pore diameters as well as to an increase of hydrophilicity degree compared to the micropaticles based only on glycidyl methacrylate. To analyze the in vitro release data various mathematical models were used, such as, first order, Higuchi model, Korsmeyer-Peppas model and Baker-Lonsdale model. Based on the highest values of the correlation coefficient, the analysis of the kinetic data indicate that drug release from G1 and X1 porous microparticles fits similarly well to the first order and Higuchi models and diffusion was the dominant mechanism of drug release.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 125, 10 July 2015, Pages 323-333
نویسندگان
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