کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7789168 | 1500635 | 2015 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chemical characteristics and antithrombotic effect of chondroitin sulfates from sturgeon skull and sturgeon backbone
ترجمه فارسی عنوان
ویژگی های شیمیایی و اثر آنتی ترومبوتیک سولفات کندرویتین از جمجمه ماهیان خاویاری و ستون فقرات ماهیان خاویاری
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کلمات کلیدی
ماهیان خاویاری کندرویتین سولفات، ضد انعقاد تجمع ضد پلاکت، ترومبولیزیسم،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Chondroitin sulfates (CSs) were extracted from sturgeon skull and backbone, and their chemical composition, anticoagulant, anti-platelet and thrombolysis activities were evaluated. The average molecular weights of CS from sturgeon skull and backbone were 38.5Â kDa and 49.2Â kDa, respectively. Disaccharide analysis indicated that the sturgeon backbone CS was primarily composed of disaccharide monosulfated in position four of the GalNAc (37.8%) and disaccharide monosulfated in position six of the GalNAc (59.6%) while sturgeon skull CS was primarily composed of nonsulfated disaccharide (74.2%). Sturgeon backbone CS showed stronger antithrombotic effect than sturgeon skull CS. Sturgeon backbone CS could significantly prolong activated partial thromboplastin time (APTT) and thrombin time (TT), inhibited ADP-induced platelet aggregation and dissolved platelet plasma clots in vitro. The results suggested that sturgeon backbone CS can be explored as a functional food with antithrombotic function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 123, 5 June 2015, Pages 454-460
Journal: Carbohydrate Polymers - Volume 123, 5 June 2015, Pages 454-460
نویسندگان
Meng Gui, Juyi Song, Lu Zhang, Shun Wang, Ruiyun Wu, Changwei Ma, Pinglan Li,