Solid lipid nanoparticles for oral drug delivery: Chitosan coating improves stability, controlled delivery, mucoadhesion and cellular uptake

- SLN was prepared by a combined technique of solvent-diffusion and hot homogenization.
- Chitosan coating stabilized SLN in simulated gastric condition.
- Chitosan coating significantly improved mucoadhesive property of SLN.
- Chitosan formed a thick layer around SLN in gastric condition as clearly observed by TEM.
- Surfactants but not chitosan coating determined cell uptake of SLN.