کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7789927 | 1500641 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Self-assembled nanoparticles of acetylated cashew gum: Characterization and evaluation as potential drug carrier
ترجمه فارسی عنوان
نانوذرات خودآموز از آدامس آستیل شده: ویژگیها و ارزیابی به عنوان حامل داروهای بالقوه
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Acetylated cashew gum (ACG) was synthesized and self-assembled nanoparticles were obtained through the dialysis of an organic solution (DMSO) against a non-solvent (water). The ACG was characterized by infrared spectroscopy. The degree of substitution was 2.8 as determined by NMR spectroscopy. The physicochemical properties of the self-assembled nanoparticles in aqueous media were characterized by DLS, SEM and fluorescence spectroscopy. The mean diameter of the self-assembled nanoparticles obtained was 179Â nm and the critical aggregation concentration (CAC) in water was 2.1Â ÃÂ 10â3Â g/L. Indomethacin (IND) was used as a hydrophobic model drug and was incorporated into the hydrophobized polysaccharide. Both loaded and unloaded nanoparticles were found to be spherical with diameters in the ranges of 70-170Â nm and 108-314Â nm (determined by SEM), respectively. Controlled drug release was observed for up to 72Â h.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 117, 6 March 2015, Pages 610-615
Journal: Carbohydrate Polymers - Volume 117, 6 March 2015, Pages 610-615
نویسندگان
Nadia A.O. Pitombeira, José Guilherme Veras Neto, Durcilene A. Silva, Judith P.A. Feitosa, Haroldo C.B. Paula, Regina C.M. de Paula,