کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7790607 | 1500644 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bacterial cellulose/acrylic acid hydrogel synthesized via electron beam irradiation: Accelerated burn wound healing in an animal model
ترجمه فارسی عنوان
هیدروژل باکتری سلولز / اکریلیک اسید توسط پرتو الکترون پرتو تولید می شود: التیام زخم سوختگی سریع در یک مدل حیوانی
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کلمات کلیدی
سلولز باکتریایی، اسید اکریلیک، زخم زدن، التیام زخم،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Natural polymer-based hydrogels are of interest to health care professionals as wound dressings owing to their ability to absorb exudates and provide hydration for healing. The aims of this study were to develop and characterize bacterial cellulose/acrylic acid (BC/AA) hydrogels synthesized by electron beam irradiation and investigate its wound healing potential in an animal model. The BC/AA hydrogels were characterized by SEM, tensile strength, water absorptivity, and water vapor transmission rate (WVTR). The cytotoxicity of the hydrogels was investigated in L929 cells. Skin irritation and wound healing properties were evaluated in Sprague-Dawley rats. BC/AA hydrogels had a macroporous network structure, high swelling ratio (4000-6000% at 24Â h), and high WVTR (2175-2280Â g/m2/day). The hydrogels were non-toxic in the cell viability assay. In vivo experiments indicated that hydrogels promoted faster wound-healing, enhanced epithelialization, and accelerated fibroblast proliferation compared to that in the control group. These results suggest that BC/AA hydrogels are promising materials for burn dressings.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 114, 19 December 2014, Pages 312-320
Journal: Carbohydrate Polymers - Volume 114, 19 December 2014, Pages 312-320
نویسندگان
Najwa Mohamad, Mohd Cairul Iqbal Mohd Amin, Manisha Pandey, Naveed Ahmad, Nor Fadilah Rajab,