کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7790721 | 1500643 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Physical properties and antibacterial activity of chitosan/acemannan mixed systems
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Physical properties and antibacterial activity of chitosan/acemannan mixed systems Physical properties and antibacterial activity of chitosan/acemannan mixed systems](/preview/png/7790721.png)
چکیده انگلیسی
The aim of the present study was to investigate the mechanical and thermal properties of mixed chitosan-acemannan (CS-AC) mixed gels and the antibacterial activity of dilute mixed solutions of both polysaccharides. Physical hydrogels of chitosan comprising varying amounts of non-gelling acemannan were prepared by controlled neutralization of chitosan using ammonia. As the overall acemannan concentration in the mixed hydrogel increased while fixing that of CS, the mechanical strength decreased. These results indicate that AC perturbs the formation of elastic junctions and overall connectivity as it occurs in the isolated CS network. Heterotypic associations between CS and AC leading to the formation of more compact microdomains may be at play in reducing the density of the gel network consolidated by CS, possibly due to shorter gel junctions. Micro-DSC studies at pH 12.0 seem consistent with the suggestion that molecular heterotypic associations between CS and AC may be at play in determining the overall physical properties of the mixed gel systems. In dilute solution, CS showed antimicrobial activity against Staphylococcus aureus but not against Escherichia coli; AC did not exert antimicrobial activity against any of the two bacterial species. In blended solutions of both polysaccharides, as the amount of AC increased, the antimicrobial activity of the system against S. aureus ceased. In conclusion, this study demonstrates that it is feasible to incorporate acemannan in chitosan-acemannan gels and that although the mechanical strength decreases due to the presence of AC, the gel network persists even at high amount of AC. This study anticipates that the CS-AC mixed gels may offer promise for the future development of biomaterials such as scaffolds to be used in wound therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 115, 22 January 2015, Pages 707-714
Journal: Carbohydrate Polymers - Volume 115, 22 January 2015, Pages 707-714
نویسندگان
Amada Yerén Escobedo-Lozano, Alain Domard, Carlos A. Velázquez, Francisco M. Goycoolea, Waldo M. Argüelles-Monal,