کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7790869 | 1500644 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Creation of macropores in three-dimensional bacterial cellulose scaffold for potential cancer cell culture
ترجمه فارسی عنوان
ایجاد ماکروپورها در داربست سلولز باکتریایی سه بعدی برای کشت سلولی بالقوه سرطان
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کلمات کلیدی
بیومارکرهای، سلولز باکتریایی، مواد متخلخل داربست، سلول سرطانی،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
There is an increasing need for an effective in vitro model that can resemble the 3-D nature of tumor microenvironments. In this work, a 3-D bacterial cellulose (BC) scaffold with macropores was fabricated by a facile freeze drying method for potential culture of cancer cells. This in vitro study reported, for the first time, the role of macropores in the adjustment of cancer cell behavior when compared with previous results cultured in BC scaffolds without macropores. The scaffold was characterized by SEM and mercury intrusion porosimeter. A human breast cancer cell line (MDA-MB-231) cultured in the macroporous BC scaffold was examined via cell proliferation, histological and SEM analyses. The results demonstrated that the macroporous scaffold provided a good environment for cell viability, adhesion, proliferation, and infiltration. These findings suggested that the macroporous BC scaffold might have great potential for use in the in vitro culture of cancer cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 114, 19 December 2014, Pages 553-557
Journal: Carbohydrate Polymers - Volume 114, 19 December 2014, Pages 553-557
نویسندگان
Guangyao Xiong, Honglin Luo, Yong Zhu, Sudha Raman, Yizao Wan,