کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7791118 | 1500646 | 2014 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of chitosan on oxidative stress and related factors in hemodialysis patients
ترجمه فارسی عنوان
اثرات کیتوزان بر استرس اکسیداتیو و عوامل مرتبط با آن در بیماران همودیالیز
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کلمات کلیدی
کیتوزان، آنتی اکسیدان، نارسایی کلیه، استرس اکسیداتیو، الزام آور،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
In recent world-wide studies, chitosans were tested as a dietary supplement for inhibiting the absorption of certain lipids and bile acids. We previously demonstrated the antioxidative and renoprotective potential of chitosan supplementation in chronic renal failure using 5/6 nephrectomized rats. In this study, we report the effects of chitosan on oxidative stress and related factors in hemodialysis patients. The ingestion of chitosan over a 12-week period resulted in a significant decrease in serum indoxyl sulfate and phosphate levels, compared with the levels prior to the start of the study. The ingestion of chitosan also resulted in a lowered ratio of oxidized to reduced albumin and a decrease in the level of advanced oxidized protein products. In in vitro studies, chitosan solutions were found to bind 38.5% of the indoxyl sulfate and 17.8% of the phosphate, respectively. Further, the oxidized albumin ratio was correlated with serum indoxyl sulfate levels in vivo. These results suggest that the ingestion of chitosan results in a significant reduction in the levels of pro-oxidants, which include uremic toxins, in the gastrointestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation. In addition, the long-term ingestion of chitosan has the potential for use in treating hyperphosphatemia in hemodialysis patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 112, 4 November 2014, Pages 152-157
Journal: Carbohydrate Polymers - Volume 112, 4 November 2014, Pages 152-157
نویسندگان
Makoto Anraku, Motoko Tanaka, Ayumu Hiraga, Kohei Nagumo, Tadashi Imafuku, Yuji Maezaki, Daisuke Iohara, Kaneto Uekama, Hiroshi Watanabe, Fumitoshi Hirayama, Toru Maruyama, Masaki Otagiri,