کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7792293 1500656 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lyophilization as a novel approach for preparation of water resistant HA fiber membranes by crosslinked with EDC
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Lyophilization as a novel approach for preparation of water resistant HA fiber membranes by crosslinked with EDC
چکیده انگلیسی
The hyaluronic acid (HA) fibers scaffold with an extracellular matrix mimic structure has been prepared via lyophilization. The morphology of the HA fibers varying the concentration from 0.05 wt% to 0.15 wt% was characterized by scanning electron microscope (SEM). The diameter of HA fibers increased and the morphology changed from fiber to sheet-like structure as the concentration of HA solution increased. To enhance the water-resistance, the pure HA fiber membranes were chemical cross-linked by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), and confirmed by fourier transform infrared (FT-IR) spectra. In vitro degradation behavior of cross-linked HA fiber membranes in both of water and PBS solutions was investigated, the physical properties were also studied by differential scanning calorimetry (DSC) and thermogravimetry (TG). The results showed that the bonding water capacity increased after crosslinking, and indicated that the crosslinked HA fibers could be used as scaffold in tissue engineering.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 102, 15 February 2014, Pages 8-11
نویسندگان
, , , , ,