Synthesis and characterization of biotin modified cholesteryl pullulan as a novel anticancer drug carrier

- New drug carrier biotin-modified cholesteryl pullulan (Bio-CHSP) has been synthesized and characterized.
- Spherical pullulan derivative nanoparticles were prepared and characterized by DLS and TEM.
- Nanoparticles were well tolerated at a single intravenous dose of 200 mg/kg in mice.
- The loading and release abilities for hydrophobic anticancer drugs were evaluated by UV.