Synthesis of NAM-thiazoline derivatives as novel O-GlcNAcase inhibitors

- Ten novel NAM-thiazoline derivatives have been synthesized for the first time as a new type of inhibition for human O-GlcNAcase.
- Several compounds have shown good inhibitory activity for human O-GlcNAcase (IC50 < 15 μM).
- One inhibitor exhibited more than 150-fold selectivity for hOGA over hHex.