Stereoselective facile synthesis of 2′-spiro pyrimidine pyranonucleosides via their key intermediate 2′-C-cyano analogues. Evaluation of their bioactivity

- A stereoselective synthesis of 2′-C-cyano pyranonucleosides was accomplished.
- 2′-Spiro nucleosides were synthesized via their key intermediate cyanohydrins.
- Structural elucidation of the synthesized compounds by NMR studies.
- Several 5-fluorouracil derivatives showed a pronounced cytostatic activity.