An alternative route for fondaparinux sodium synthesis via selective hydrogenations and sulfation of appropriate pentasaccharides

► An alternative way for fondaparinux synthesis from an appropriate pentasaccharide. ► One-pot O- and N-sulfation of protected pentasaccharide. ► Selective hydrogenation of N-Cbz and azide groups in the presence of O-Bn. ► Applying continuous flow hydrogenation reactor. ► Applying catalytic hydrogen transfer conditions.