Synthesis of 2-fluoro and 4-fluoro galactopyranosyl phosphonate analogues of UDP-Gal

► 2(4)-Deoxy-2(4)-fluoro-α,d-galactopyranosyl phosphonates were key intermediates. ► Fluorine was introduced first by nucleophilic substitution. ► Triethyl phosphite reacts with 2(4)-deoxy-2(4)-fluoro-α,d-galactopyranosyl acetate.