Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH)

A series of pyrazole phenylcyclohexylcarbamate derivatives standing on the known carbamoyl FAAH inhibitor URB597 was prepared. The most active compounds of this series showed significant selectivity toward monoacylglycerol lipase (MAGL) enzyme. Among the screened compounds, the 3-(3-(ethoxycarbonyl)-1-phenyl-1H-pyrazol-5-yl)phenyl cyclohexylcarbamate (22) showed high inhibitor activity (IC50 = 11 nM).