Comparison of biodegradable poly(glycolide-ɛ-caprolactone) and poly(glycolide-ɛ-caprolactone-d,l-lactide) coatings enriched with ciprofloxacin formed on Ti6Al4V alloy

Biodegradable coatings containing caprolactone units additionally enriched with ciprofloxacin formed on Ti6Al4V alloys have been developed. The polymer coatings were investigated as a carrier for ciprofloxacin-antibacterial drug. Coatings have been obtained according to the dip-coating method. Two kinds of polymers containing caprolactone units have been used: poly(glycolide-ɛ-caprolactone) and poly(glycolide-ɛ-caprolactone-d,l-lactide). The properties of the layered metal/polymer + drug system have been presented and the influence of the kind of polymer on the drug release has been evaluated. Different types of drug release profile depend on the type of used system. The CFX release from poly(glycolide-ɛ-caprolactone) is uniform with one stage, contrary to poly(glycolide-ɛ-caprolactone-d,l-lactide). The mechanism of ciprofloxacin release from GCap and GCapL matrices is different. The release from GCap and GCapL matrix fit to the Peppas-Sahlin and Korsmeyer-Peppas model, respectively. The release exponent indicates anomalous transport for GCap and case II transport for GCapL.