کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7823967 | 1502860 | 2018 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel biocompatible PBS-based random copolymers containing PEG-like sequences for biomedical applications: From drug delivery to tissue engineering
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel biocompatible PBS-based random copolymers containing PEG-like sequences for biomedical applications: From drug delivery to tissue engineering Novel biocompatible PBS-based random copolymers containing PEG-like sequences for biomedical applications: From drug delivery to tissue engineering](/preview/png/7823967.png)
چکیده انگلیسی
A series of random poly(butylene succinate)-based copolymers, (poly(butylene/triethylene succinate) (P(BSmTESn)), containing ether-oxygen atoms were successfully synthesized by melt polycondensation of succinic acid and 1,4-butanediol in the presence of triethylene glycol (TEG) (TEG content up to 40â¯mol%). The copolymers were characterized from the molecular, thermal, structural and mechanical point of view. Hydrolytic degradation studies were performed under physiological conditions. The biocompatibility of the samples under investigation through indirect and direct biocompatibility studies was investigated by using embryonic rat cardiac H9c2 cells. To evaluate the potential of these polymers also for controlled drug delivery systems, the diffusion profile of Dexamethasone, an anti-inflammatory drug, through nanoparticles prepared by oil-in-water miniemulsion process was investigated. Results showed that solid-state properties could be tailored nicely by simply varying copolymer composition. Crystallinity degree and hydrophobicity significantly decreased with the increase of triethylene succinate co-unit (TES) mol%. Moreover, hydrolytic degradation of PBS, depending on polymer crystallinity degree and hydrophilicity, was remarkably improved: the copolymer containing 40â¯mol% of triethylene succinate co-unit after 200 days lost over 22% of its initial weight. The newly developed biomaterials showed lack of cell cytotoxicity. Among them, PBS and the copolymers containing up to 20â¯mol% of TES co-units sustained a better cell adhesion and proliferation. In addition, such copolymers induced muscle phenotype commitment in H9c2 cells cultured onboard. Lastly, the release profile of Dexamethasone obeyed to a first order kinetic law, the copolymer richest in TES co-unit content showing the highest encapsulation capability and the fastest drug release kinetics. Anyway, PBS and the copolymers containing up to 20â¯mol% of TES co-unis sustained a better cell adhesion and proliferation, with the copolymers characterized by a myosin heavy chain expression, which appeared to be up to twofold increased on respect to the one of PBS homopolymer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer Degradation and Stability - Volume 153, July 2018, Pages 53-62
Journal: Polymer Degradation and Stability - Volume 153, July 2018, Pages 53-62
نویسندگان
Martina Fabbri, Giulia Guidotti, Michelina Soccio, Nadia Lotti, Marco Govoni, Emanuele Giordano, Massimo Gazzano, Rita Gamberini, Bianca Rimini, Andrea Munari,