کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7824190 1502866 2018 30 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tuning the structure and performance of silk biomaterials by combining mulberry and non-mulberry silk fibroin
ترجمه فارسی عنوان
تنظیم ساختار و عملکرد بیومارایهای ابریشم با ترکیب فیبرین ابریشم طلایی و غیر توبره
کلمات کلیدی
مواد زیستی پروتئین ابریشم، ژلاتین، ویژگی های مکانیکی، تنزل،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
Despite considerable efforts toward the biomedical applications of silk fibroin (SF), detailed control of structure and performance in silk biomaterials remains a major challenge. Silks are classified as mulberry and non-mulberry, which are produced by domesticated Bombyx mori and wild silkworm species, respectively. To achieve silk biomaterials with tunable performance, Bombyx mori silk fibroin (BSF) and non-mulberry Antheraea pernyi silk fibroin (ASF) were blended. These systems exploit the beneficial material and biological properties of both silk proteins. The sol-gel transition of ASF was much more rapid than that of BSF. Consequently, the gelation rate of SF solution could be controlled ranging from tens of minutes to days by changing the ASF ratio, providing useful options for the fabrication of silk hydrogels. Raising BSF ratio in the blend materials significantly increased mechanical performance, overcoming the inherent lack of mechanical performances of regenerated ASF materials. Conversely, increasing ASF ratio significantly enhanced degradability of the blend films, providing a wider range of regulation for the degradation rate of silk biomaterials. As a result, this simple blending strategy enables the process to be more controllable and flexible, controlling the performance of silk protein becomes feasible, and this would greatly expand the applications of silk as a biomedical material.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Polymer Degradation and Stability - Volume 147, January 2018, Pages 57-63
نویسندگان
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