کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7826328 | 1503036 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bioactive Ti-base biomaterial with sustained anti-bacterial response for endosseous applications
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
This paper aims to develop a bioactive biomaterial based on porous titanium coated with chitosan (Chi) hydrogel film (Chihf), which releases antibiotic, for tissue engineering of bone. The chosen antibiotic was Tetracycline (Tet); as a carrier, we used core-shell microcapsules of Bovine Serum Albumin (BSA) gel with k-carrageenan/chitosan polyelectrolite complex multilayer shell (ms). The structures of both Chihf and Tet-loaded microcapsules (Tet-ms) were characterized by: FTIR, XRD, SEM, CLSM, Fluorescence spectroscopy, and Fluorescence optical microscopy. The Tet release in pHâ¯7.4 PBS is much slower from Tet-ms embedded in Chihf than simply from Tet-ms. The values of mechanical properties of Chi films reveal significant adhesiveness to the “skin model” film, a good premise for implant anchorage and osseointegration. The in vitro biological study of the film that releases the antibiotic indicates a good biocompatibility and the assessment of antibacterial activity shows a prolonged release of Tet, avoiding the biofilm formation and its adhesion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 125, April 2018, Pages 37-46
Journal: Reactive and Functional Polymers - Volume 125, April 2018, Pages 37-46
نویسندگان
Violeta PaÅcalÄu, George Dindelegan, Noemi Dirzu, Ana-Maria Salantiu, Codruta Pavel, Mircea Cristian Dudescu, Florin Popa, Gheorghe Borodi, Flaviu Tabaran, Cristina Adela Iuga, Catalin Popa,