کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7826384 | 1503037 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enhanced hemocompatibility of flat and hollow fiber membranes via a heparin free surface crosslinking strategy
ترجمه فارسی عنوان
همی سازگاری از غشاهای فیبر مسطح و توخالی با استفاده از یک استراتژی متقابل سطح هپارین
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کلمات کلیدی
هماهنگی غشای همودیالیز، بدون هپارین هپارین تقلید، میکرو تورم،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Insufficient hemocompatibility is challenging for current dialysis membranes. The current modification methods have some limitations in effectiveness, practicality and cost. Herein, we develop a heparin-free crosslinking approach to enhance the hemocompatibility of both the flat (polylactide) and hollow fiber (polysulfone) membranes with heparin-mimicking surface. Poly (triethoxyvinylsilane-N-vinyl-2-pyrrolidone) (P (VTES-VP)) is first introduced to the membrane surface to improve the hydrophilicity, which is facilitated to the adsorption and further crosslinking of poly (triethoxyvinylsilane-Acrylic acid-Sodium 4-vinylbenzenssulfonate) (P(VTES-AA-SSNa)). The mixture of N, N-dimethylacetamide (DMAc) and water was modulated for good solubility, swelling and adsorption of precopolymer. The chemical structure of the heparin-mimicking membrane was confirmed by attenuated total reflectance Fourier transform infrared spectra (FTIR-ATR), X-ray photoelectron spectroscopy (XPS), weight measurement and scanning electron microscopy (SEM). The hydrophilicity was improved by the heparin-mimicking surface. Moreover, the heparin-mimicking membranes presents higher platelet resistance, prolonged coagulation time (APTT for ~Â 180.1Â s), decreased Plasma fibrinogen (FIB for ~Â 122Â mg/dL), and suppressed complement activation. More importantly, the heparin-free crosslinking approach can be utilized to significantly enhance the hemocompatibility of commercial PSF hollow fiber membranes, indicating its potential application in heparin free dialyzers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 124, March 2018, Pages 104-114
Journal: Reactive and Functional Polymers - Volume 124, March 2018, Pages 104-114
نویسندگان
Hui Wang, Jinglong Li, Fu Liu, Tiantian Li, Yun Zhong, Haibo Lin, Jidong He,