کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7853515 | 1508873 | 2014 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biodistribution of PEGylated graphene oxide nanoribbons and their application in cancer chemo-photothermal therapy
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی انرژی
انرژی (عمومی)
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چکیده انگلیسی
To use graphene oxide nanoribbons (GONRs) in combination with chemo-photothermal therapy, we modified GONRs with phospholipid-polyethylene glycol (PL-PEG) to prepare PEGylated GONRs (PL-PEG-GONRs), followed by investigation of the short-term in vivo biodistribution of 99mTc-labeled PL-PEG-GONRs and their excretion in mice. The 99mTc-labeled PL-PEG-GONRs demonstrated a unique biodistribution pattern of rapid accumulation in and excretion from the liver. Moreover, we determined that the PL-PEG-GNORs were excreted from the body through the renal route in urine, and we used hematological analysis to show that the PL-PEG-GNORs were not toxic in vivo. Furthermore, doxorubicin-loaded PL-PEG-GONRs had IC50 values for chemo-photothermal therapy toward U87 glioma cells that were 6.7-fold lower than the IC50 values in traditional chemotherapy. With these advantages, PL-PEG-GONRs could be used as drug nanocarriers to develop an efficient cancer-therapy strategy that would not only improve the efficacy of the therapy, but would also reduce the risk of side effects of the nanocarrier in the body.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbon - Volume 74, August 2014, Pages 83-95
Journal: Carbon - Volume 74, August 2014, Pages 83-95
نویسندگان
Yu-Jen Lu, Chih-Wen Lin, Hung-Wei Yang, Kun-Ju Lin, Shiaw-Pyng Wey, Chia-Liang Sun, Kuo-Chen Wei, Tzu-Chen Yen, Ching-I Lin, Chen-Chi M. Ma, Jyh-Ping Chen,