کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7866241 | 1509131 | 2018 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neurogenic differentiation of adipose derived stem cells on graphene-based mat
ترجمه فارسی عنوان
تمایز نوروژنیک سلول های بنیادی مشتق شده از بافت چربی بر روی گرافیتی مبتنی بر گرافن
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کلمات کلیدی
گرافن، تمایز نوروژنیک، سلول های بنیادی مشتق شده از چربی، زیست سازگاری، مهندسی بافت عصبی،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
چکیده انگلیسی
Adipose derived stem cells (ADSCs) have been proved as an abundant and accessible cell source with the ability to differentiate into neuron-like cells. However, the low differentiation efficiency puts forward an important challenge to practical applications in clinic. Considering of the good biocompatibility of graphene-based materials and the potential interaction between graphene and cells mentioned in previous studies, herein, we investigated the effect of graphene oxide (GO) and reduced graphene oxide (rGO) mats on neurogenic differentiation of the ADSCs. We demonstrated the excellent capabilities of graphene-based mats, especially GO to support the neural differentiation of ADSCs. By comparing the observation under an optical microscope and fluorescence microscope, the conversion rate of neuron-like cells reached about 90%. We consider that GO mat is better for promoting the differentiation of ADSCs into neuron-like cells, which compared to rGO based platforms. Meanwhile, we made an analysis of the mechanism by which graphene induced the differentiation of ADSCs to neuron-like cells. The data obtained here highlight the effect of GO mat on neurogenic differentiation of ADSCs and implicate the potential of graphene-based materials in application of neural tissue engineering for the limited self-repair capability of nerve cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 90, 1 September 2018, Pages 685-692
Journal: Materials Science and Engineering: C - Volume 90, 1 September 2018, Pages 685-692
نویسندگان
Zhang-Qi Feng, Ke Yan, Chuanmei Shi, Xuran Xu, Ting Wang, Ruitao Li, Wei Dong, Jie Zheng,