کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7866377 | 1509133 | 2018 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Repair of full-thickness articular cartilage defect using stem cell-encapsulated thermogel
ترجمه فارسی عنوان
تعمیر ضخامت مفصلی غضروف مفصلی با استفاده از ترموگل محصور شده توسط سلول های بنیادی
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کلمات کلیدی
ترموگل پلیمری سلول های بنیادی، تعمیر غضروف مفصلی، پزشکی بازسازی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
چکیده انگلیسی
Cartilage defect repair by hydrogel-based tissue engineering is becoming one of the most potential treatment strategies. In this work, a thermogel of triblock copolymer poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide) (PLGAâPEGâPLGA) was prepared as scaffold of bone marrow mesenchymal stem cells (BMMSCs) for repair of full-thickness articular cartilage defect. At first, the copolymer solution showed a reversible solâgel transition at physiological temperature range, and the mechanical properties of such thermogel were high enough to support the repair of cartilage. Additionally, excellent biodegradability and biocompatibility of the thermogel were demonstrated. By implanting the BMMSC-encapsulated thermogel into the full-thickness articular cartilage defect (5.0â¯mm in diameter and 4.0â¯mm in depth) in the rabbit, it was found that the regenerated cartilage integrated well with the surrounding normal cartilage and subchondral bone at 12â¯weeks post-surgery. The upregulated expression of glycosaminoglycan and type II collagen in the repaired cartilage, and the comparable biomechanical properties with normal cartilage suggested that the cell-encapsulated PLGAâPEGâPLGA thermogel had great potential in serving as the promising scaffold for cartilage regeneration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 88, 1 July 2018, Pages 79-87
Journal: Materials Science and Engineering: C - Volume 88, 1 July 2018, Pages 79-87
نویسندگان
Yanbo Zhang, Jin Zhang, Fei Chang, Weiguo Xu, Jianxun Ding,