کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7866735 | 1509151 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of inorganic/organic ratio and chemical coupling on the performance of porous silica/chitosan hybrid scaffolds
ترجمه فارسی عنوان
اثر نسبت معدنی / ارگانیک و اتصال شیمیایی بر روی عملکرد داربست های هیبرید سیلیس متخلخل / کیتوزان
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کلمات کلیدی
ترکیبی، کیتوزان، سیتو سازگاری، سل ژل، بازسازی بافت،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
چکیده انگلیسی
Inorganic/organic hybrid scaffolds have great potential for tissue engineering applications due to controllable mechanical properties and tailorable biodegradation. Here, silica/chitosan hybrid scaffolds were fabricated through the sol-gel method with a freeze drying process. 3-Glycidoxypropyl trimethoxysilane (GPTMS) and tetraethylorthosilicate (TEOS) were used as the covalent inorganic/organic coupling agent and the separate inorganic source, respectively. Hybrid scaffolds with various inorganic/organic weight ratios (I/Os) and molar ratios of chitosan and GPTMS (GCs) were examined and compared in this study. FTIR showed that higher GPTMS content resulted in the increased covalent cross-linking of the chitosan and the silica network in hybrids. Compression testing indicated that increasing the GPTMS content greatly improved the compressive strength of scaffold. LIVE/DEAD assay showed that enhanced cytocompatibility was obtained as the silica content increased. Therefore, the results confirmed that the two parameters I/O and GC can largely influence the scaffold performance, which can be used to tailor the hybrid properties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 70, Part 2, 1 January 2017, Pages 969-975
Journal: Materials Science and Engineering: C - Volume 70, Part 2, 1 January 2017, Pages 969-975
نویسندگان
Daming Wang, Wei Liu, Qian Feng, Chaoqun Dong, Qisong Liu, Li Duan, Jianghong Huang, Weimin Zhu, Zemeng Li, Jianyi Xiong, Yujie Liang, Jielin Chen, Rong Sun, Liming Bian, Daping Wang,