کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7867564 | 1509159 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hydrothermal fabrication of porous hollow hydroxyapatite microspheres for a drug delivery system
ترجمه فارسی عنوان
تولید هیدروترمال میکروسپرسهای هیدروکسی آپاتیت توخالی متخلخل برای یک سیستم تحویل دارویی
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کلمات کلیدی
هیدروکسی آپاتیت، کربنات کلسیم، میکروسپورهای توخالی، سیستم تحویل دارو،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
چکیده انگلیسی
Porous hollow hydroxyapatite microspheres (PHHMs) are the promising biomaterials, owing to their excellent biocompatibility, biodegradability and bioactivity. PHHMs have been used as drug controlled carriers due to their advantages such as large drug loading capacity, nanochannels for drug loading and release and high specific surface area. In this study, PHHMs were prepared successfully in Na2HPO4 solution by an anion-exchange process using vaterite CaCO3 through a hydrothermal method. The previous vaterite CaCO3 was synthesized by a polymer-templated method in the poly(styrene sulfonic acid) sodium salt (PSS) aqueous solutions. The PHHMs have a size distribution from 0.8 to 2.0 μm, with an average pore size of about 24.3 nm. The wall of PHHMs is constructed with building units of hydroxyapatite nanofibers with an average length of 300 nm and an average width of 20 nm. The PHHMs displayed a high drug loading capacity and pH-responsive sustained-controlled drug release behavior when we used doxorubicin hydrochloride (DOX) as a loading drug. Moreover, the controlled drug release system showed a high ability to kill cancer cells and less damage to normal cells. These results indicated that PHHMs are promising for applications in various biomedical fields such as drug delivery system and oncotherapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 62, 1 May 2016, Pages 166-172
Journal: Materials Science and Engineering: C - Volume 62, 1 May 2016, Pages 166-172
نویسندگان
Wen Lai, Cen Chen, Xiaoyuan Ren, In-Seop Lee, Guohua Jiang, Xiangdong Kong,